miércoles, 26 de enero de 2011

Mechanisms of action

Iodine is used in medical practice for over 150 years for the treatment of wounds, the surgical field in dentistry and for the treatment of skin diseases. It reacts not only with proteins of microorganisms, but also the microorganism to form a typical film on the surface of the wound, which prevents the penetration of pathogenic bacteria. However, quite often just under the skin there is inflammatory.

Domestic researchers have developed a drug YODDITSERIN, which penetrates deeply into the lesion tissue. What is his zest and edge over other iodine-containing drugs?

Its distinguishing feature - no irritating effect, and the ability to brand viagra penetrate deeply into tissue, where the breed germs of inflammatory processes. YODDITSERIN makes full use of certain antimicrobial action of iodine directly in living tissues without damaging them. In the finished dosage form of germicidal iodine cation, solvated by a monomolecular layer of aprotic solvents - dimethyl sulfoxide, is balanced by the anion, which is not dimethyl sulfoxide solvated. As the dissolution medium used triatomic alcohol glycerin, do not react with iodine ions and dimethyl sulfoxide. Such a stable ion system with an anhydrous phase in the treatment of patients with purulent infection dynamically transformed. She very quickly penetrates into tissues, bypassing the blood and lymphatic flow, due to the lipophilicity of dimethyl sulfoxide, while attending his desolvation, thus liberated active iodine cations, which are the focus of purulent infection have an antimicrobial effect. The depth of penetration of the drug by the time of his application. When working with cultures of microorganisms YODDITSERIN for speed and minimal bactericidal concentrations exceed counterparts. The drug penetrates the purulent inflammatory foci, does not cause pain and tissue irritation. YODDITSERIN applied topically (tampons, turundas, wipes, wraps, etc.), and is suitable for application to mucous membranes.

The drug was widely used in surgical practice, it can also be used in combination with other drugs, such as ointments, which include antibiotics. Drug resistance of pathogens of purulent infection in YODDITSERIN does not develop. Some of the advantages by which physicians choose this drug, it should be emphasized that all the components YODDITSERINA pharmacologically active. He has a broad spectrum of antimicrobial activity, has anti-edematous, antinekroticheskim and anti-inflammatory action.

In various phases of wound healing process is also effective Eton gel 1% of JSC "Pharmak. It is bactericidal, and anesthetic wound-healing effect. Eton gel 1% cleans wounds, promotes granulation, which leads to faster healing of the wound surface. Its successful use as a phase of alteration, and during the granulation than the drug and is different from most of ointments used in surgical practice.

According to the chemical structure of Eton refers to a group bischetvertichnoe ammonium compounds. The mechanism of antimicrobial action of these substances is a change in the synthesis of cell wall components of pathogens.

Eton gel 1% stimulates the regeneration, cleans staphylococcal toxin, has anesthetic action.

Given the multivalency of the drug, its use is indicated for treatment of purulent surgical wounds, postoperative wounds, burns, II and IIIA degrees of trophic ulcers and prevention of infectious complications in household injuries.

The lesion causing the gel 1-2 times a day (until negative results of microbiological investigations) within 1-2 weeks. After the standard treatment of trophic ulcers, wounds and burns gel put on the wound surface with a sterile gauze bandage. Tampons impregnated with gel, fill the cavity of septic wounds after surgical treatment, or irrigation with antiseptic solution, and gauze turundas gel injected into the fistula. In the treatment of septic wounds gel using 1 time per day, for treatment of burns - every day or 2-3 times per week depending on the condition of the wound. The amount of drug determined by the degree of purulent exudate, the duration of treatment depends on the purification and healing.

Application Eton gel 1% is shown as in the phases of alteration and exudation, and at the stage of regeneration, which avoids the need for multiple drugs with different mechanisms of action and at the same time, greatly enhance the effectiveness of treatment.

Effectiveness of the drug is determined not only Eton - the active substance, but also adjuvants that promote deeper penetration of the drug in the tissue and enhance its therapeutic activity.

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jueves, 20 de enero de 2011

Postoperative mortality

Suturing, including parenchymal brand viagra online abdominal organs is accompanied by formation of connective tissue adhesions (adhesions). Development of the local adhesive process can cause the formation of intestinal obstruction and / or chronic pain syndrome (adhesive peritoneal disease). Article authors compared the ability of different classes of surgical threads contribute adgeziogenezu after surgery.

The recurrent problem of general surgery is still the problem of hemostasis of generic viagra parenchymal organs with their trauma and surgical interventions. At present, new ways of stopping parenchymal bleeding, hemostatic offers modern facilities.

Objective: to evaluate the nature and extent of morphological changes in the abdominal cavity with the use of catgut and Dacron for applying hemostatic sutures to the liver and spleen in an experiment.

Materials and methods. Experimental studies were conducted on 12 mongrel dogs of both sexes. Animals were divided into two experimental brand name levitra series. Under general anesthesia in sterile conditions following the standard model of the liver and spleen injuries in the first series was carried out hemostasis by cialis without prescription catgut sutures, and the second - lavsan. Animals were removed from the experiment in 14 days by an overdose of intravenous anesthetic, performed an autopsy, the standard histological examination. The obtained data were processed statistically.

Results of their research. In the postoperative mortality and complications. In the place of injury was determined by adhesions in all cases. Its intensity was 2,45 ± 0,87 points method of semantic differential.

Cicatricial changes in parenchymatous organ injury with generic levitra subsequent suturing the Dacron filaments are characterized by the formation of a dense scar with less severe cell infiltration in comparison with the series, which used catgut. There is considerable destruction of catgut in 14 days, compared with virtually unmodified Dacron filaments. Formed connective tissue in podpaivanii omentum in surgery in a series using catgut has less maturity and a significant inflammatory infiltration compared with the series, which was used dacron. Micromorphological evidence about the development of prolonged inflammation at the site of implantation of catgut. Thus the rationality of using catgut in surgery requires a review and study of reactions of biological tissues in vivo implantation in these sutures and the other used in modern medicine explants of definite practical interest.

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domingo, 9 de enero de 2011

Long courses

CLASSIFICATION OF STAGES OF ARTERIAL DISEASE OF LOWER LIMB

Ability to walk is the basis of classification of chronic arterial insufficiency of lower extremities in the severity of the disease - the classification of Fontaine, which is somewhat modified by us as shown below.

Stage 1

leg pain occur only after a rather long walk (about 1 km)
Stage 2a
patient passes (average pitch) over 200 m
Stage 2b
the patient is less than 200 m
Stage 3a
characterized by the appearance of "rest pain, pain that is occurring in a horizontal position, forcing the patient to periodically lower the leg down (up to 3-4 times per night)
Stage 3b
(Critical ischemia) - appears ischemic edema of the leg and foot. The patient is forced to drop the leg more than 3-4 times per night
Stage 4a
(Critical ischemia) - developed necrotic changes in the toes, when there is the prospect of saving in a subsequent reference limb function
Stage 4b

gangrene of the foot or lower leg, requiring amputation of a high

MAIN most frequently used to treat patients HOZANK, DRUGS

Acetylsalicylic acid: used in small doses (rheologically active), 100 - 150 mg daily or every other day. The drug used practically for life, except when the patient is receiving other drugs in the same manner affecting the flow properties of blood. There are forms of acetylsalicylic brand viagra acid with enteric-coated, which provides security for the gastric mucosa and creates conditions for prolonged use.
Pentoxifylline. Its modern therapeutic dose of 1200 mg / day. There are forms - tablets with slow, sustained release 400 mg of active substance (1 tablet 3 times a day). If you are using pentoxifylline in tablets of 100 mg, it should take a dose of at least 2 tablets. 3-4 times per day. Duration of treatment 3-6 months. During intravenous infusion of pentoxifylline at the same time the patient should receive him and in tablets to maintain a constant blood concentrations and the therapeutic effect within days. But we should remember that the total dose was given intravenous and oral administration should not exceed 1200 mg / day.
Ticlopidine - one of the most view of normal men potent platelet Antiaggregant. Particularly effective in severe stages of the disease and diabetic angiopathy. It is used long-course dose of 1 tablet (250 mg) 2 times a day. When applied to take aspirin is not needed.
Dipyridamole. Dose should be 75 mg 3 times a day. Course of treatment 2-3 months. It is advisable to combine with low-dose aspirin.
DRUGS nicotinic acid (nicotinate ksantinola). Dose: 2 tablets (300 mg) 3 times a day for 2-3 months. It is advisable to combine with low-dose aspirin.
Drugs for disorders of lipid metabolism. Used long courses under the supervision of investigations of lipid metabolism. Their purpose must be preceded by an attempt to diet.
GEMOPREPARATY. Actovegin is used inside of 1-2 tablets 3 times daily before meals or intravenously at a dose of 10 to 50 ml of the drug in the 200-300 mg saline solution or in the form of a specially prepared solution (10 or 20%) in bottles of 250 ml. Treatment course - 10-20 injections.
Calcium antagonists. Currently applied nifedipine and verapamil (finoptin). It is advisable to use retardirovannye form.
SYSTEMIC ENZYME - A new method of treatment based on pill containing a complex of enzymes (flogenzim, Wobenzym). Optimizes the natural physiological processes in the body, improves blood circulation. Course of treatment 3-6 months. Very important regimen of these drugs: for 30-40 minutes before eating, drinking plenty of water.
EXTRACT Ginkgo Biloba. The main active principle Tanakan - a standardized extract of Ginkgo biloba (EGb 761). Dose: 2 tablets 2 times a day. The course of treatment for 2-3 months. The drug is a beneficial effect on brain metabolism, eliminates the headache, dizziness, and improves memory. The drug improves blood rheology, microcirculation, has a positive effect on the vasomotor response of large blood vessels. Normalizes metabolic processes, have antihypoxia action on the fabric. Indications: encephalopathy, arteriopathy of the lower extremities. Effective with the combined pathology.
Alprostadil - the most effective in the treatment of critical ischemia. For clinical efficacy is important to introduce the recommended dose, ie 3 capsules, intravenously once a day for at least 2 weeks. Perhaps its application without other concomitant drugs used to treat HOZANK. Active ingredient of the drug is prostaglandin E1 (PGE1).

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domingo, 2 de enero de 2011

Pollinosis

"The soul of every body has his blood," says the Bible. This red liquid is surrounded by a halo of holiness at all times.

Held together by blood oaths, her neighbor gave as a gift to charity. Due to the investigation of its properties, detect the presence of infections, treacherously introduced into the human body. Have blood and other destinations. Thanks to its clean-up of circulating toxins and wastes it, you can prevent the development of a serious condition. It's about plasmapheresis - a universal, but now unfairly relegated to the side technique of purification of blood, once widespread throughout the world.

Word of our expert - a doctor-Transfusion, head of the office of extracorporeal blood purification and Andrew Zvonkov.

From time immemorial

Historical predecessor of therapeutic plasmapheresis is phlebotomy, in which the healing power of faith, dating back to ancient times and until the late nineteenth century. Blowing blood, medieval witch doctors were trying to relieve suffering from various ailments. And in some cases, this they succeeded: lowering blood viscosity, healers, past and hypertensive crises averted, and fevers were taken. But at the same time without even knowing about, and stimulated immunity zanemogshih.

And all would be good if the distant brand name viagra predecessors of today's doctors transfusiologists - barbers - knew the measure. Excessive bleeding often led to the development of the patients lethal condition called disseminated intravascular coagulation syndrome (severe bleeding disorder due to a massive release of thrombogenic substances and factors antisvertyvaniya). As a result, the number of injured from too zealous use of the popular method of healing was significantly greater than the number of those who needed it. The official medical bloodletting recognized by voodoo and wild.

The situation changed by the beginning of the twentieth century, when replaced by a rough and unsafe for the health of manipulation came plasmapheresis procedure - removal of some amounts of blood and its subsequent division into fractions (components), the liquid part of which (plasma) is removed and cleaned the blood - cell mass returns the bloodstream patient. Thus doctors transfusion were able not only to thin the blood, reducing its viscosity and improving blood flow to organs and tissues of the patient, but also able to liberate it from the waste products of cells - toxins and other harmful substances that contribute to the emergence and development of many diseases.

Nothing more!

At first glance resembles the usual procedure of plasmapheresis dropper. The only difference that the blood withdrawn from a vein (usually no more than 450-500 ml per cycle, and the session may consist of two such cycles) is divided into special centrifuge for cell mass and plasma, from which to get rid of. Then the remaining cell mass is diluted with saline and returned back to the client.

The number and duration of these sessions, as well as the amount of purified blood depends on many factors. Writing an individual program for each patient, physicians take into account the transfusion of his height, weight, and his health. After all, as any method of treatment, plasmapheresis has its contraindications. Among them - a violation phasing properties of the blood, low hemoglobin level and blood pressure, acute stage of infection and purulent inflammation and cancer, including those that are in remission: plasmapheresis activates the immune system and can upset the delicate balance after successful chemotherapy.

In all other cases, plasmapheresis only helps to restore health. Its used successfully to treat and prevent nearly 200 different diseases and syndromes, including as serious as diabetes, psoriasis, eczema, hypertension, coronary heart disease, cholecystitis, pancreatitis, etc. hepatosis

Seven woes - one answer!

Plasmapheresis is indispensable for those who suffer from pollinosis (severe allergic reaction to the flowering plants), as well as atopic (allergic to the library and house dust). These patients come in for a session of plasmapheresis in the midst of a worsening, or (for hay fever) before the pollen season - to clean the blood of antibodies that cause them to suffocate, sneezing and coughing.

The real magic wand was plasmapheresis in the treatment of toxicoses of the first and second half of pregnancy, as well as placental insufficiency, which is the main cause of fetal hypoxia (oxygen starvation) and fetal growth retardation. One procedure to clean up the blood in two weeks - and the expectant mother and her baby is in perfect order! Not to mention that and look after plasmapheresis pregnant woman will be much more beautiful: improving the transport properties of blood, he also has a pronounced anti-aging effect. Is it because the West the vast number of donors of blood plasma - women aged 30 to 50 years?

Plasmapheresis is useful for men. Especially for those who abuse the strong drinks. True, along with toxins from the blood alcohol drinker alcohol washed out and splitting enzymes, which increases sensitivity to alcohol. These patients, doctors must warn: alcohol intake (even in small doses) after the procedure, plasmapheresis is contraindicated.

Increases the clearance of blood and susceptibility to drug therapy. But this is rather an additional advantage of the universal technique. According to Andrei Zvonkova to him often refer patients to colleagues and doctors (gynecologists, urologists, dermatologists, psychiatrists), where the designated Viagra in the future course of medical treatment does not achieve the desired effect.

It would seem, for the medical plasmapheresis - a real find: either you expensive equipment, no extra costs for his conduct. But no: medical centers (both here and abroad) where the professional conduct this procedure can be counted on the fingers. Experts do not despair: meek still find them the road. However, for the desire to improve your health by cleaning the blood, they will pay.

By the way

In addition to plasmapheresis, in which there are dozens of varieties, a very effective method of treatment is another method of cleaning the blood - it ultraviolet radiation (UFOK). This technique is a more advanced variant autohemotherapy - treatment of the patient's own blood, which is intramuscular or subcutaneous injection to the patient's own blood taken from a vein, in order to stimulate the protective functions of the body and improve metabolism, as well as for the treatment of indolent disease and infections.

At the core lies UFOK irradiation a small amount of blood that passes through the light of ultraviolet light of low power, equal to the intensity of sunlight in the ultraviolet spectrum. Then treated in this way the blood is returned to the patient.

Immunostimulating and anti-inflammatory effect of this procedure is felt after the first sessions, which are shown in the treatment of: purulent processes (cellulitis, boils, etc.), indolent disease (pyelonephritis, chronic inflammatory diseases of upper respiratory tract), gastric ulcer and 12 duodenal intestine, obstructive lung disease. Contraindicated UFOK conducting the procedure for cancer, the presence of viral infection (influenza, AIDS (HIV), hepatitis, etc.).

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